Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/12754
Title: Peculiarities of pathogenesis of complications with account of immuno-physiological disorders in acute response to trauma
Authors: Isaev, Michael Vladimirovich
Ivanova, Yuliya Viktorovna
Syrovaya, Anna Olegovna
Makarov, Vladimir Aleksandrovich
Makarov, Vitali Vladimirovich
Tishakova, Tatyana Stanislavovna
Keywords: traumatic disease
systemic inflammation response syndrome
multiple organ dysfunction syndrome
pathogenesis
Issue Date: 20-Apr-2016
Citation: Peculiarities of pathogenesis of complications with account of immuno-physiological disorders in acute response to trauma / M. V. Isaev, A. O. Syrovaya, Y. V. Ivanova, V. A. Makarov, V. V. Makarov, T. S. Tishakova // Der Pharmacia Lettre. – 2016. – № 8 (5). – Р. 184–188.
Abstract: Mechanisms associated with the development of systemic inflammation response syndrome (SIRS) are of great importance in the progression of multiple organ dysfunction syndrome, traumatic disease and progression of pyoinflammatory complications. This study has been shown that period of acute response to trauma corresponds to the period of shock and early postshock period (first two days), which is characterized by hypovolemia and perfusion deficiency. To restore homeostasis allelically-determined powerful energetic mechanisms of urgent adaptation (hypermetabolism), changing the character of carbohydrate, protein and fat metabolism, are involved. Above-noted mechanisms become exhausted that results in decompensation (fatal case) or at adequate treatment functional dominance switches on the mechanisms of long-term adaptation, ensuring restoration of sustainable living. The character of the early and late complications is predetermined by the degree of immunogenic and metabolic disturbances.
URI: http://repo.knmu.edu.ua/handle/123456789/12754
ISSN: 0975-5071
Appears in Collections:Наукові праці. Кафедра медичної та біоорганічної хімії

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