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Title: Investigation of quantum-chemical properties of indomethacin
Authors: Syrovaya, Anna Olegovna
Kozub, Svetlana Nikolaevna
Tishakova, Tatyana Stanislavovna
Levashova, Olga Leonidovna
Chalenko, Natalya Nikolaevna
Keywords: Indomethacin,
spatial structure,
quantum-chemical properties.
Issue Date: 2017
Citation: Investigation of quantum-chemical properties of indomethacin / A. O. Syrovaya, S. N. Kozub, T. S. Tishakova, O. L. Levashova, N. N. Chalenko // The scientific heritage. – 2017. – N 16 (16). – P. 11–15.
Abstract: The quantum-chemical properties of indomethacin were determined. These properties are very important for understanding explanation the causes of the manifestation of certain biological effects. The geometry optimization for indomethacin molecule was performed by PM3 method, Polak-Ribiere algorithm. Pharmacological activity of a molecule depends not only on the character and sequence of atoms, but also on their spatial distribution in the molecule, atomic charges, position of the functional groups and active radicals, quantum-chemical properties.
Appears in Collections:Наукові праці. Кафедра медичної та біоорганічної хімії

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