Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/19368
Title: The experimental research on the antiinflammatory action of the new piroxicamcaffeine pharmaceutical composition
Authors: Syrova, Ganna Olegivna
Lukianova, Larisa Volodimirivna
Chalenko, Natalia Mikolaivna
Keywords: piroxicam
caffeine
pharmaceutical composition
anti-inflammatory effect
formalin edema
Issue Date: 2018
Citation: Syrova G. O. The experimental research on the antiinflammatory action of the new piroxicamcaffeine pharmaceutical composition / G. O. Syrova, L. V. Lukianova, N. M. Chalenko // Science Review. – 2018. – Vol. 4, № 3(10). – P. 72–76.
Abstract: Conducting an experimental research on laboratory rats subjected to endogastric injections, our scientists have explored the influence of the non-steroid anti-inflamatory drug from the oxicam group piroxicam (4-hydroxo-2-methyl-N-pyridine-2-il)-2H-1,2-benzothiazine-3-carboxamide1,1- dioxyde), a well-known adjuvant of non-narcotic analgetics and non-steroid anti-inflamatory drugs such as caffeine (1,3,7-trimethylxanthine)and the two-component piroxicam-caffeine pharmaceutical composition on the rats’ anti-exudative activity under formalin edema. The analysis of the results of the experimental researches points to the fact that caffeine promotes the anti-exudative action of piroxicam in the rats under formalin edema. The above-mentioned experimental researches allow us to come to the conclusion that due to its vasoconstrictive effect caffeine performs as an adjuvant to piroxicam (a non-steroid anti-inflamatory drug from the oxicam group) concerning the anti-exudative activity. The results of the research can become a basis for the development of new combined drugs in Ukraine.
URI: http://repo.knmu.edu.ua/handle/123456789/19368
Appears in Collections:Наукові праці. Кафедра медичної та біоорганічної хімії

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