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|Название: ||Heart rate variability, large vessel remodelling and metabolic parameters in stage 1 hypertension according to the ACC/AHA 2017 guidelines|
|Авторы: ||Shalimova, Anna|
|Ключевые слова: ||Heart rate variability|
large vessel remodeling
|Issue Date: ||2018|
|Библиографическое описание: ||Heart rate variability, large vessel remodelling and metabolic parameters in stage 1 hypertension according to the ACC/AHA 2017 guidelines / A. Shalimova, B. Graff, A. Szyndler, J. Wolf, M. Blaszkowska, E. Orlowska-Kunikowska, B. Wolnik, K. Narkiewicz // Journal of Hypertension. – Vol. 36, e-Suppl. 1. – e166.|
|Аннотация: ||Objective: Controversial defi nition of arterial hypertension (AH) by the ACC/AHA
2017 Guidelines renewed interest in the earlier stages of blood pressure (BP) elevation.
The aim: to investigate the features of the heart rate variability (HRV), large
vessel remodelling (VR) and metabolic parameters in subjects with stage 1 AH
according to the new American guidelines (130–139 / or 80–89 mmHg).
Design and method: We investigated 148 untreated subjects with the following
BP levels (mmHg): < 120 / and < 80 (group 1; n = 33), 120–129 / and < 80
(group 2; n = 27), 130–139 / or 80–89 (group 3; n = 60), > = 140 / or > = 90
mmHg (group 4; n = 28). HRV indices were assessed by 24-hour Holter monitoring
data, large vessel remodelling parameters - on the basis of applanation tonometry
(Sphygmocor) and carotid echo-tracking (Artlab) data. The results are
presented as mean ± standard deviation.
Results: In comparison to group 1, group 2 had lower levels the high-density
lipoproteins levels (61.7 ± 15.6 and 51.7 ± 11.6 mg/dl, respectively, p = 0.009),
increased diameter of carotid artery (6.8 ± 0.4 and 7.5 ± 0.5 mm, respectively,
p = 0.034) and similar pattern of HRV parameters. Group 3, compared to groups
1 and 2, had signifi cantly higher glucose and uric acid levels (p = 0.045 and
p = 0.017, respectively), and also increased carotid-femoral pulse wave velocity,
compared to groups 1 (7.8 ± 1.2 and 7.2 ± 0.9 m/s, respectively, p = 0.025). These
alterations were associated with an increase in the high-frequency component of
HRV (HF, p = 0.013 and r-MSSD, p = 0.022) and greater distensibility of the carotid
vascular wall (p = 0.004), which were not observed in the group 4.
Conclusions: Subjects with blood pressure of 130–139 / or 80–89 mmHg are
characterized by distinct metabolic abnormalities, initial signs of vascular remodelling
and alterations of HRV, which might predispose to further progression of BP
elevation and development of target organ damage.|
|Appears in Collections:||Наукові праці. Кафедра внутрішньої медицини № 1|
Наукові праці. Кафедра внутрішньої медицини № 1
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