Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/27588
Title: Association between RANKL rs9594759 and IL10 rs1800896 gene polymorphisms and deciduous tooth eruption terms in ukrainians born macrosomic
Authors: Гармаш, Ольга Володимирівна
Россоха, З.І.
Горовенко, Н.І.
Garmаsh, Olga
Rossokha, Z.
Gorovenko, N.
Keywords: fetal macrosomia
deciduous teeth
CYP19A1 [rs2414096]
ESR1 [rs9340799]
IL-10 [rs1800896]
RANKL: C> T [rs9594759] genes polymorphism
Issue Date: 2020
Citation: Garmash O. V. Association between RANKL rs9594759 and IL10 rs1800896 gene polymorphisms and deciduous tooth eruption terms in ukrainians born macrosomic / O. V. Garmash, Z. I. Rossokha, N. G. Gorovenko // Wiadomosci lekarskie. – 2020. – T. 73, nr 2. – S. 342–351.
Abstract: The aim: The article deals with analyzing the influence of polymorphic variants of CYP19A1 [rs2414096, rs936306], ESR1 [rs2234693, rs9340799], IL1 [rs1143627], IL6 [rs1800796], IL10 [rs1800896] and RANKL [rs959389] genes on deciduous tooth eruption terms in individuals born macrosomic. Materials and methods: 171 individuals participated in the multi-stage study (144 macosomic-at-birth individuals and 27 normosomic-at-birth persons). This study included only persons who have preserved information about the timing of deciduous tooth eruption – 159 persons (aged from 4 to 55 years), male and female (male / female ratio was 1.5 / 1). Results and conclusions: The presence of the G allele in CYP19A1 [rs2414096] gene and the -351 A allele in ESR1 [rs9340799] gene were found to be risk factors for fetalmacrosomia formation. The research revealed an association of RANKL [rs9594759] gene variants which is a multiplicative model of inheritance and IL-10 [rs1800896], an overdominant model of inheritance, with an increased risk of tooth delay. Besides the variants of RANKL [rs9594759] and IL-10 [rs1800896] genes a multidirectional modifying effect on the timing of tooth eruption in macrosomic-at-birth individuals made the variant of CYP19A1 [rs2414096] gene – a significant dominant and over-dominant model of inheritance. Further analysis of intergenic interactions will facilitate the application of the obtained results in clinical practice by creating a molecular profile of individuals with deviations in the tooth eruption timing.
URI: http://repo.knmu.edu.ua/handle/123456789/27588
Appears in Collections:Наукові праці. Кафедра терапевтичної стоматології

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