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|Название: ||Particularities of inflammatory markers changes in patients with chronic kidney disease complicated with arterial hypertension|
|Авторы: ||Shelest, Borys Oleksiyovich|
Shatilova, Julia Igorevna
Kycherenko, Danil Olegovich
|Ключевые слова: ||hypertension|
chronic kidney disease
|Issue Date: ||May-2013|
|Библиографическое описание: ||Shelest B. O. Particularities of inflammatory markers changes in patients with chronic kidney disease complicated with arterial hypertension / B. O. Shelest, J. I. Shatilova, D. O. Kycherenko // 6th International Scientific Interdisciplinary Conference (ISIC) for medical students and young doctors, Kharkiv, 16-17 May 2013 : Abstract book / KhNMU. – Kharkiv, 2013. – Р. 107-108.|
|Аннотация: ||The aim was to study the dynamics of inflammatory markers CRP, IL-1β, IL-4, TNF-α − under the influence of hypertension in patients with CKD.
Methods: Included in the study 56 patients with CKD, the first group (n=27) was represented by patients with high blood pressure (BP) systolic blood pressure> 140 mm Hg., BP diastolic <90 mm Hg., the second group - patients with CKD and normal values of BP. The control group consisted of 20 healthy individuals. Cytokines and CRP levels were determined by ELISA.
Results and discussion. Revealed a significant increase of inflammatory markers CRP, IL-1β, TNF-α in patients with CKD compared with the control group, whereas anti-inflammatory IL-4 was reduced. For chronic kidney disease with hypertension were characterized by the increasing in CRP, TNF-α and IL-1β and decreasing of anti-inflammatory interleukin-4. It is important to note, that in comparison with the group of patients with normal pressure, patients with hypertension had significantly elevated levels of TNF-α (65,25 ± 4,57, p<0,05).
Conclusions. Joining hypertension to CKD leads to greater activation of the inflammatory process in these patients. The level of anti-inflammatory IL-4 was almost equally low in both groups, compared with controls, regardless of the presence of hypertension.|
|Appears in Collections:||Навчально-методичні видання. Кафедра внутрішніх та професійних хвороб|
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