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Title: Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4- dihydropyrimidine-2(1H)-thiones
Authors: Kharchenko, Juliya V.
Detistov, Oleksandr S.
Orlov, Valeriy D.
Keywords: 1,2,4-oxadiazole
combinatorial synthesis
liquid-phase route
Issue Date: 2009
Publisher: American Chemical Society
Citation: Kharchenko Juliya V. Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones / Ju. V. Kharchenko, O. S. Detistov, V. D. Orlov // J. Comb. Chem. – 2009. – Vol. 11. – P. 216–219.
Abstract: We have developed a liquid-phase route for combinatorial synthesis of novel substituted 5-(1,2,4-oxadiazol-5-yl)-3,4 dihydropyrimidine-2(1H)-thiones. Biginelli-type three-component condensation of 1-(3 aryl-1,2,4-oxadiazol-5-yl)acetones, thiourea, and benzaldehydes is shown to result in new 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thione heterocyclic system. If salicylaldehydes are used in this reaction, a mixture of 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones and 11-(1,2,4-oxadiazol-5-yl)-2,3,5,6-tetrahydro-4H-2,6-methano-1,3,5-benzoxadiazocine-4-thiones is formed.
ISSN: 1520-4766
Appears in Collections:Наукові праці. Кафедра медичної та біоорганічної хімії

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