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|Title:||Isomeric 3-isoxadiazolylcoumarins and their derivatives|
|Citation:||Detistov O. S. Іsomeric 3-isoxadiazolylcoumarins and their derivatives / O. S. Detistov, V. D. Orlov, I. O. Zhuravel` // J. Heterocyclic Chem. – 2012. – Vol. 49. – P. 883–892.|
|Abstract:||Here we represent preparative methods of synthesis of isomeric 3-isoxadiazolylcoumarins and their derivatives. Two new synthetic methods have been developed for 3-[1,2,4-oxadiazol-5-yl]coumarins I. The first method is based on a three-component condensation of coumarin-3-carboxylic acids, CDI and amidoximes. The second method essentially uses the interaction of 5-cyanomethyl-1,2,4-oxadiazoles with salicylic aldehydes. General approach for preparation of 3-[1,2,4-oxadiazol-3-yl]coumarins II has been worked out. Moreover, above mentioned synthetic ways open the way for the synthesis of 2-iminoderivatives III and IV not described before, those were diversified by reaction of nucliophilic substitution of 2-imino group with a numerous amino compounds.|
|Appears in Collections:||Наукові праці. Кафедра медичної та біоорганічної хімії|
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